the effect of progesterone treatment after ovarian induction on endometrial vegf gene expression and its receptors in mice at pre-implatation time
نویسندگان
چکیده
objective(s): progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. it is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. material and methods: adult female nmri mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimulation]. uterine horn samples removed at pre-implantation time in each group. motic image plus 2 software was used to assess the quantitative vascular parameters of endometrium. gene expression was determined for vascular endothelial growth factor (vegf), fms-like tyrosine kinase (flt) and kinase insert domain protein receptor (flk)genes using the real time pcr method. data analysis was done with linreg pcr and rest-rg software. results: comparison between progestrone treated mice after ovarian stimulation with control group showed that increase in rate of vegf gene expression [0.775] and decrease in rate of flk [6.072] and flt [1.711] gene expression. analysis of the data on quantitative vascular parameters were indicated remarkable increase in quantitative vascular parameters of progestrone treated mice compare to control group. conclusion: biological effect of progestrone on the vascular changes after ovarian stimulation resulted in an increase in vegf receptors experession, it seems that induced angiogenesis by progesterone could result in better condition for implantation.
منابع مشابه
The effect of progesterone treatment after ovarian induction on endometrial VEGF gene expression and its receptors in mice at pre-implatation time
Objective(s): Progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. It is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. Material and Methods: Adult female NMRI mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...
متن کاملThe effect of progesterone treatment after ovarian induction on endometrial VEGF gene expression and its receptors in mice at pre-implantation time.
OBJECTIVES Progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. It is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. MATERIAL AND METHODS Adult female NMRI mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimula...
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15 صفحه اولprogesterone shifts the pinopodes expression of mouse endometrium to pre-implantation time after ovarian hyperstimulation
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۹، شماره ۳، صفحات ۲۵۲-۲۵۷
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